Restoring Your Patients' Health by Conquering Their Dysbiosis

by Dr. Greg Fors, DC - Board Certified Neurologist DIBCN

Most patients today have some overt signs or symptoms of gastrointestinal distress. Nearly 20 million adults are newly diagnosed with digestive disorders each year and over 100 million individuals suffer daily from digestive disorders such as: GERD, gastritis, peptic ulcer, IBS, IBD and colitis. Furthermore, research now links digestive dysfunction to disorders you see as a clinician on a daily basis, such as: chronic muscle and joint pain, arthritis, headaches, fibromyalgia, chronic fatigue, ADHD, autism, asthma, allergies, eczema and many more. How can this be?

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About 80% of your patient's immune system exists within their gastrointestinal tract. Within a healthy digestive tract there are about one hundred trillion bacteria, more than 10x the number of cells in the body, and about 99% of these bacteria come from 30 to 40 species. The total weight of this healthy gastrointestinal bacterial flora is around 3 to 6 pounds. It is this healthy mix of beneficial bacteria in the absence of unwanted microbes that keep your patient's immune system in proper balance. Research is showing that alteration in this bowel flora, called Dysbiosis, is a contributing factor to many chronic and degenerative diseases. Gastrointestinal dysbiosis is best understood as 'an over abundance of non-acute non-infectious GI microorganisms and/or a lack of beneficial bacteria, adversely affecting the human host.' This definition is vital to understand.

The imbalanced microbial growth need not come from acute infectious bacterial agents to cause chronic gastrointestinal or systemic problems. Because of the high concentration of the immune system within the G.I. tract, non-acute non-infectious commensal or non-beneficial bacteria and their endotoxins in large numbers can activate your patient's immune system. This many times leads to an enhanced inflammatory response either locally in the patient's G.I. tract and/or systemically. There are numerous factors in our modern lifestyle that can lead to this dysbiotic flora imbalance, chief among them are overuse of antibiotics, poor diet, hypochlorhydria and maldigestion. If these factors can be eliminated or at least reduced, natural treatments aimed at ridding your patient of dysbiosis may be more successful.

When your patient suffers from pain and inflammation, which is chronic and difficult to overcome, it is vital to consider that the inflammation is triggered or enhanced by the presence of dysbiosis. It is my experience in practice that three out of four patients with inflammatory disorders or chronic pain have dysbiosis. The presence of dysbiosis in my patients has been verified via Comprehensive Digestive Stool Analysis through a specialty laboratory. In my clinic, a CDSA is completed on any patient with symptoms of inflammatory disease or complaints of chronic muscle and joint pain.

Research has verified my clinical observations. In one particular study, roughly 70% of patients with chronic arthritis were carriers of asymptomatic infections, potentially triggering the inflammatory response in their synovial fluid.(1) In another study, a little more than half of patients with undifferentiated oligoarthritis had intestinal enteric bacteria identified as a causative agent of their inflammation and arthritis.(2) If you are not finding dysbiosis in your patients with chronic inflammation and pain, it may be that you are not looking for it. It is easy enough to find, all you need to do is call one of the specialty labs below to set up an account and start testing your patients for dysbiosis:

Genova Diagnostics 63 Zillicoa Street Asheville, NC 28801 at 800-522-4762
Doctor's Data, Inc.3755 Illinois Avenue St. Charles, IL 60174 at 800.323.2784
Metametrix Clinical Lab 3425 Corporate Way Duluth, GA 30096 at 800-221-4640

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Antimicrobial treatments ("poison the microbes, not the patient"): Plant-based NO-simple carbohydrate diets have been shown to improve the quality and quantity of beneficial intestinal microflora. Sugars and simple carbohydrates have been shown to feed the growth of unwelcome bacteria and yeast. Hypoallergenic diets have also proven beneficial for the treatment of dysbiosis. There are also specific antimicrobial botanicals that can be used to directly kill or strongly inhibit unwanted intestinal microbes. The most effective and well-documented botanicals are discussed below and utilized in BIOSPEC's Dysbi-Ease. Botanicals for antimicrobial treatment are frequently continued for one to three months, and are co-administered with very concentrated probiotics. These products must be taken three hours away from any antimicrobial botanicals. I have found antimicrobial drugs are sometimes necessary for acute and/or severe infections. However, dietary, nutritional and botanical interventions are safer and often more effective.

Research-based effective botanical medicines are best used in combination. Generally, dosage recommendations are intended for adults who are otherwise healthy; lower doses are appropriate for children, the elderly and patients with renal or hepatic insufficiency.

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Berberine Sulfate, the King of the antimicrobial botanicals is a very specific active alkaloid from Berberis plants. This specific Berberine Sulfate alkaloid extract is more expensive, but is worth it because of its broad antimicrobial activity, showing effectiveness against Giardia, Candida, and Streptococcus.(3) It has also proven to be active against protozoa and fungi.(4) Research has shown Berberine to be an effective therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae, having direct anti-inflammatory and anti-diarrhea actions; it is also relatively nontoxic to humans.(5) An oral dose of 400 mg per day is common for adults.(6) Berberine is generally non-toxic at recommended doses, but it is not recommended for use during pregnancy.

Myrrh Gum Extract (Commiphora molmol; methanol extract) specific methanol extract demonstrates antibacterial activity against Staphylococcus aureus and even MRSA strains.(7) Myrrh is also remarkably effective against parasitic infections.(8) A recent clinical trial against schistosomiasis showed "The parasitological cure rate after three months was 97.4 percent and 96.2 percent for S. haematobium and S. mansoni cases, a marvelous clinical cure without any side-effects."(9)

Artemesia Annua has primarily been used for treatment of protozoan infection, though it has also proven effective against anaerobic bacteria, due to the pro-oxidative sesquiterpene endoperoxide. One of the additional benefits of Artemesia annua is its systemic bioavailability.

Calcium Undecylenate is an extremely effective, broad-spectrum, well-tolerated anti-fungal. When treating dysbiosis it is always vital to include a very effective antifungal in your formula. Current studies indicate this extract of castor bean oil is up to 30 times more effective in combating Candida Albicans than Caprylic Acid. When tested over a pH range from 4.5 to 6.0, the antifungal activities of calcium undecylenate are quite pronounced. However, above pH 6.0, the calcium salt is less active.

Biospec's Dysbi-Ease features specific extracts including Berberine Sulfate alkaloids, Myrrh Gum methanol extraction, and the anti-fungal Calcium Undecylenate delivered at a proper pH.

Two (2) tablets provide:

  • Calcium Undecylenate....................................................................... 500 mg
  • Myrrh Gum Extract (commiphora molmol; methanol extract).................................... 300 mg
  • Artemesia Annua............................................................................ 300 mg
  • Berberine Sulfate specific (berbaris aristata root extract)................................ 200 mg

Form: 120 Tablets - Product: 989

Recommendations: As a nutritional supplement for adults, 2 or 3 tablets daily for 2 weeks or as directed by your Healthcare Professional. If Dysbiosis and accompanying symptoms are not completely resolved within 2 weeks, a repeat course may be necessary. Always use Probiotic-5 while taking this product. Take these products at least 3 hours apart.

WARNING: Do not use if pregnant or nursing.
NOTE: For best results, use with a quality probiotic, such as Probiotic-5, taken 3 hours apart.

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BIOSPEC's CLINICAL UPDATES
with Dr. Greg Fors

Biospec Nutritionals has been serving health care professionals for over 20 years and remains committed to innovation and the highest quality formulas at prices patients can afford. As a cornerstone of our company, we remain committed to education and the most recent developments in nutritional medicine. Please call us direct at 1(800)825-7921 should you ever have any questions about our formulas or would like more detailed product literature for your practice. One of us will always be available to ensure your needs are met.

Dr. Greg Fors, D.C. is the Chief Science Consultant for Biospec Nutritionals, a Board-certified Neurologist (IBCN), certified in Applied Herbal Sciences (NWHSU) and acupuncture. Trained through the Autism Research Institute he is a registered 'Defeat Autism Now!' Doctor. As the clinic director of the Pain and Brain Healing Center in Blaine Minnesota he specializes in a natural biomedical approach to fibromyalgia, fatigue, depression, autism and ADHD. He is a sought after international lecturer for various post graduate departments and state associations. Dr. Fors is the author of the highly acclaimed book, "Why We Hurt" available through booksellers everywhere.

FOOTNOTES

  1. Weyand CM, Goronzy JJ. Ann Rheum Dis. 1992 Feb; 51(2):253-8.
  2. Fendler C, Laitko S, et.al. Ann Rheum Dis. 2001 Apr; 60(4):337-43.
  3. Amin AH, Subbaiah TV. Abbasi KM. Can J Microbiol 1969;15:1067-1076.
  4. Kaneda Y, et al. Annals Trop Med Parasitol 1991;85:417-425.
  5. Rabbani, G. H., 1987. J. Infect. Dis. 155:979-984.
  6. Berberine. Altern Med Rev. 2000 Apr;5(2):175-7.
  7. Emad M. Abdallah1, Amna S. Khalid1 Scientific Research Berberine. Altern Med Rev. 2000 Apr;5(2):175-7and Essay Vol. 4 (4) pp. 351-356, April, 2009.
  8. El Baz MA et al. J Egypt Soc Parasitol. 2003 Dec; 33(3):761-76.
  9. Abo-Madyan AA, Morsy TA, Motawea SM. J Egypt Soc Parasitol. 2004 Aug; 34(2):423-46.